Rodrigo Moreno, Isco and Thiago Alcantara scored within 11 first-half minutes to ensure victory for the 2010 tournament winners.
"We have a very good mix of veterans and youngsters", said Thiago.
Victory in Jerusalem is necessary for La Roja if they want to be top seeds in the draw for the World Cup group stage, which will be made on December 1.
Gerard Pique was jeered in Alicante on Friday, as he routinely is on Spain duty, for his outspoken defence of Catalonia's right to self-determination, although he has never publicly backed independence.More news: Egypt's Chances of Passing Group Qualifications Improves after Uganda and Ghana Draw
"He's been in the Spanish national team for 15 years and shown his commitment, but people are free to whistle and think whatever they want".
Serbia got off to the flawless start when Luka Milivojevic gave them an 11th minute lead. Tom Lawrence scored for the Welsh side with Arsenal's Aaron Ramsey the provider.
In Group I, Berg Gudmundsson and Birkir Bjarnason gave Iceland a two-goal cushion heading into half-time in Istanbul and things got even better for Heimir Hallgrimsson's team four minutes into the second half when Kari Arnason extended the lead. Despite this, Albanian team for today after 8 rounds in the current qualifying cycle, earned 13 points with a goal difference of 10: 9 and takes 3rd place in the standings.
The result, coupled with Spain's 3-0 win over Albania, ensured that Italy will finish second in Group G, nearly certainly guaranteeing it a place in a two-leg playoff. "In order to play a good game, we need the fans cheering us on".More news: Trump to Decertify Nuclear Deal With Iran
Spain have a terrific 35-3 scoring record during the campaign, conceding only against Italy, in their 4-1 win over Israel and a tougher than expected 2-1 win in Macedonia.
Iceland look set to return to the world stage after unexpectedly reaching the quarter-finals at the European Championships a year ago.
Ukraine are level on 17 points with Croatia following a 2-0 win away to Kosovo and host the Croats in Kiev on Monday.More news: TV Reporter Accuses Harvey Weinstein of Forcing Her to Watch Him Masturbate
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