The study, which took place in Denmark and France, included 31 adult men under the age of 35.
The research, which was published in the Proceedings of the National Academy of Sciences journal, showed that the men who took the high doses of ibuprofen developed the disorder known as compensated hypogonadism.
With regard to long-term ibuprofen use, "It is also of concern that men with compensated hypogonadism may eventually progress to overt primary hypogonadism".
Those in the ibuprofen group were given two doses of ibuprofen a day.More news: Fire breaks out at Trump Tower in New York City, FDNY says
The findings are certainly significant, as the 1,200mg of ibuprofen given to the participants each day is far below the suggested daily maximum of 3,200mg per day.
A new study suggests that some men who regularly take the anti-inflammatory drug ibuprofen could be doing serious damage to their testicles, or at least the stuff stored inside them, CNN reported Tuesday.
The French National Institute of Health and Medical Research's Bernard Jegou, a senior author of the study, said that there is no problem in taking ibuprofen for short-term pain relief.
"These compounds are good painkillers, but a certain amount of people in society use them without thinking of them as proper medicines", David Møbjerg Kristensen at the University of Copenhagen told the newspaper.More news: H&M apologizes for ad of black boy in 'Coolest Monkey' hoodie
Researchers even tested ibuprofen on "bits of human testes" collected from organ donors and saw the same result: The drug hampered testosterone output.
The Consumer Healthcare Products Association, a trade group that represents manufacturers of over-the-counter medications and supplements, "supports and encourages continued research and promotes ongoing consumer education to help ensure safe use of OTC medicines", Mike Tringale, a spokesman for the association, told CNN.
The hormonal imbalance caused compensated hypogonadism, which is a condition linked to decreased male fertility, depression, and an increased risk of heart attack or stroke.
According to scientists, these men may also experience erectile dysfunction, fatigue, and muscle wastage, as prolonged ibuprofen usage disrupted testosterone hormones. This is because the pituitary gland at the base of the brain had ramped up levels of another hormone that drives the production of extra testosterone.More news: Former Google Engineer Who Wrote Diversity Memo Files Suit
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