Two early goals saw Uruguay finish top of group A as they inflicted Russia's first defeat of the World Cup in Samara, winning 3-0 to make it three victories from three and leave the hosts in second place.
But it was South Americans who opened the scoring as Surarez sent a low-free kick from just outside the area into the bottom right corner in the 10th minute.
The goal for Suarez is his second of the World Cup, which leads Uruguay.
Denis Cheryshev's own goal compounded Russia's misery 13 minutes later, with Smolnikov's dismissal - for a second yellow card issued after a foul on Edinson Cavani prior to half time - all but ending hopes of a comeback.More news: 5000 people take part in Indian Embassy Yoga Day celebrations
Things went from bad to worse for the tournament hosts when they were reduced to 10 men when Igor Smolnikov picked up his second yellow card after 36 minutes.
However, Uruguay nearly extended its lead in the 80th minute when Cavani and Suarez raced forward with only one defender to deal with.
Russian Federation were increasingly ragged and, after Igor Smolnikov had gone into the book for a foul on Vecino, they were nearly three down when Bentancur was denied by Akinfeev.
England's opening World Cup game against Tunisia, when Kane scored a stoppage-time goal to seal a 2-1 win, was the most watched program in Britain in 2018 with a peak audience of 18.3 million - more than last month's royal wedding when Prince Harry married Meghan Markle.
"Even though we had ten men we wanted to play". Round of 16 permutations and scenarios- World Cup Daily live blog: Follow the action on and off the pitch- World Cup fixtures, results and coverage - How to fix Argentina?More news: European Union leaders tackle political flare-up over migrants
Uruguay, by contrast, are perfectly set-up to keep teams at arm's length and they had few problems during a second period that at times meandered to a procession, Edinson Cavani converting from close range in the final minute to complete a comfortable 3-0 victory.
Russia's best chance fell to Dzyuba, who fired well wide of the far post from the right side of the box.
Samara is looking forward to hosting a top-of-the-table contest in Group A when Uruguay take on hosts Russian Federation with the title of "group winner" at stake.
Cavani sealed the win on 90 minutes by tapping home the rebound, after Akinfeev had parried Godin's header.
Russia, meanwhile, will face Group B winners Spain after last night's 2-2 draw with Morocco.More news: Rudy doubt for Germany with broken nose
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