Anderson, who won the fifth set 26-24, appeared to be more annoyed.
"John is a great guy and I feel for him", Anderson told the BBC after Friday's match.
Isner has history for playing long matches at Wimbledon, having endured a 70-68 fifth-set tiebreak against Nicolas Mahut in 2010, a match which spanned three days. The fifth set lasted 175 minutes. "Just disappointed to lose".
"At that stage, you're just trying to fight in every single moment", he said.
He had also gone five sets to beat eight-time champion Roger Federer in the quarter-finals, winning the decider 13-11. Between that and the energy-sapper against Isner, it's hard to imagine how Anderson will have much left for his second Slam final.
At least Anderson can boast of one runner-up finish, and it was recent, against Nadal at last year's U.S. Open. There could be a rematch now.More news: London pub renames itself The Trump Arms ahead of presidential visit
Nadal and Djokovic will clash in a box office Wimbledon semi-final on Friday night, with the victor of the 52nd instalment of their epic rivalry to face either Isner or Anderson in Sunday's championship decider.
The last men's semifinal to be finished on Saturday was in 2007, between none other than Nadal and Djokovic.
After playing his worst game of the match, Djokovic then played his best, breaking Nadal with a fabulous cross-court passing shot to get the set back on serve.
I really hope this a sign for grand slams to change this format. "I mean, I'm a big part of that, a big part of this discussion, of course". "We want to see Rafa!" Isner and Anderson have played each other before professionally and they were rivals in college (Isner, 33, played at the University of Georgia, and Anderson, 32, at University of Illinois). But this one was as close as can be.
There was not a ton of intrigue or momentum shifts, not a whole lot of memorable shotmaking, either, save for some impressive return winners. Not a tremendous amount of memorable shotmaking, either, save for some impressive return winners. The serving, though, was something else. Both wore a white baseball hat, Anderson with the brim in front, Isner with his turned his backward. The victor of the match will face off against the victor of John Isner and Kevin Anderson.
Both failed to seize early opportunities.
Both players had set points on their own serve, and both were denied until Anderson scooped a forehand wide and Isner was ahead. The crowd. they're pretty antsy for us to get off the court.
Could he actually come through?More news: Judge orders Paul Manafort moved to suburban Washington jail
At 24-24 in the fifth set Kevin Anderson slipped on the baseline and dropped his racket.
Stunned, Isner hit the net and eventually lost the game.
Tennis matches generally do not carry on quite like this - unless they involve John Isner.
"Right now I feel awful".
"So, I apologise if I'm not more excited right now.so many mixed emotions in getting through something like that".
"I personally don't see the added value or benefit compared to, say, at the US Open where we're playing tie-breaks in the fifth set". The most important came with Isner serving at 24-24.
Anderson had nearly surely forced the game back to deuce with a close-range dink over the net, but a exhausted Isner somehow stormed across the court to slam home a passing victor.More news: Ostapenko & Kerber in to Wimbledon last four
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